Beneficial effects of statins on perioperative cardiovascular outcome.
نویسندگان
چکیده
PURPOSE OF REVIEW This review evaluates clinical and experimental articles that have recently been published on the cardioprotective effect of perioperative statin therapy. RECENT FINDINGS Perioperative statin therapy improves short and long-term cardiac outcome following noncardiac surgery. This cardiovascular protection has been attributed to the so-called pleiotropic effects, which have a positive effect on plaque stability. With no clinical studies reporting an increased incidence of adverse effects of perioperative statin use, it appears to be a safe and helpful therapeutic option. SUMMARY Perioperative statin therapy may stabilize coronary plaques due to pleiotropic effects and results in a reduction of perioperative cardiovascular complications.
منابع مشابه
Statins for surgical patients.
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There is growing evidence that statin use is associated with a reduction in perioperative morbidity and mortality. Statins inhibit 3-hydroxy3-methylglutaryl coenzyme A reductase, a mechanism that effectively reduces low-density lipoprotein cholesterol. Numerous randomized controlled studies have shown that this intervention effectively impedes the development of atherosclerosis and attenuates c...
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OBJECTIVE To determine the strength of evidence underlying recommendations for use of statins during the perioperative period to reduce the risk of cardiovascular events. DESIGN Systematic review of studies with concurrent control groups. DATA SOURCES Four electronic databases, the references of identified studies, international experts on perioperative medicine, and the authors of the prim...
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ورودعنوان ژورنال:
- Current opinion in anaesthesiology
دوره 19 4 شماره
صفحات -
تاریخ انتشار 2006